Acute promyelocytic leukaemia: A central South African experience
نویسندگان
چکیده
The South African Journal of Oncology is a peer-reviewed on-line journal which publishes high quality articles on all aspects oncology. Editorial Board strongly supports multidisciplinary approach to cancer care research as well translational in
منابع مشابه
Acute Promyelocytic Leukaemia
Acute promyelocytic leukemia (APL) represents 15 % of acute myeloid leukaemia. Prior to tretinoin usage, the treatment of APL was difficult and remission rates were low especially in developing countries due to mortality resulting primarily from bleeding'. APL is associated with a coagulopathy which may be due to a combination of disseminated intravascular coagulation and primary fibrinolysis. ...
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To cite: Jain A, Lad D, Malhotra P, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016217457 DESCRIPTION Examination of the oral cavity provides valuable clues to a large number of systemic disorders. Gum hypertrophy is usually associated with myelomonocytic and monocytic subtypes of acute myeloid leukaemia. Its occurrence in a case of acute promyelocytic...
متن کاملRecent advances in acute promyelocytic leukaemia
Acute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA fusion gene. Over the past three decades, APML has been transformed from a highly fatal disease to a highly curable one. This drastic improvement is because of the introduction of a new treatment strategy with all-trans re...
متن کاملCentral nervous system relapse in acute promyelocytic leukaemia treated with ATRA.
All-trans retinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukaemia (APL). However, there has been increasing concern that ATRA is associated with unusual sites of relapse. We present three cases of APL previously treated with ATRA who ultimately relapsed within the central nervous system (CNS) and hypothesize that, by up-regulating intercellular adhe...
متن کاملAcute promyelocytic leukaemia presenting with subarachnoid haemorrhage and complicated by central nervous system involvement
Acute promyelocytic leukaemia (APML) is a condition classically characterised by t(15;17) (q22, q21), with disseminated intravascular coagulopathy (DIC) being a major cause of death. Central nervous system (CNS) involvement with APML commonly occurs in relapse; however, it is rarely seen at presentation, with only six reported cases in the literature. This case is the first to describe a patien...
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ژورنال
عنوان ژورنال: South African journal of oncology
سال: 2022
ISSN: ['2518-8704', '2523-0646']
DOI: https://doi.org/10.4102/sajo.v6i0.245